Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity
نویسندگان
چکیده
منابع مشابه
Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity.
Retinol binding protein 4 (RBP4) is a novel adipokine which might be involved in the development of insulin resistance. The aim of the study was to investigate the expression of RBP4 mRNA in subcutaneous and visceral fat depots and the relationship between RBP4 plasma and mRNA levels relative to indices of adiposity and insulin resistance. In 59 Caucasian women (BMI 20 to 49 kg/m(2)) paired sam...
متن کاملRetinol-binding protein 4 in human obesity.
Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes. In contrast to the animal data, RBP4 mRNA was downregulated in subcutaneous...
متن کاملHigh circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.
OBJECTIVE Retinol-binding protein 4 (RBP4) is an adipokine that induced insulin resistance in mice, and high plasma RBP4 levels were associated with insulin-resistant states in humans. To determine which fat compartments are associated with elevated RBP4 levels in humans, we measured circulating RBP4 in 75 healthy subjects and used state-of-the-art measurements of body fat distribution. RESEA...
متن کاملVisceral and subcutaneous fat
Radiol Bras. 2014 Mai/Jun;47(3):IX Obesity is currently a public health problem, presenting prevalent exponential growth in all age groups, particularly in children and adolescents. Accumulation of visceral fat is associated with increased cardiovascular risk, metabolic syndrome (hypertension, dyslipidemia, type II diabetes) and insulin resistance. There is a greater correlation than that with ...
متن کاملAbdominal visceral fat reduction is associated with favorable changes of serum retinol binding protein-4 in nondiabetic subjects.
The adipocytokine retinol binding protein-4 (RBP4) has recently been shown to link obesity and insulin resistance, although their relationship remains controversial in human studies. The influence of weight reduction with changes of fat distribution on serum RBP4 concentration in nondiabetics is also unknown. We assessed the effect of weight reduction (especially abdominal visceral fat loss) on...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2008
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.931379